Patient Zero: Plague game
Brightika, Inc.
About this game
- Category Simulation
- Age 10
- Updated Aug 27, 2025
- OS IOS
Editor reviews
Become the spark that starts a global outbreak in Patient Zero: Plague game, a deep strategy-simulation where every mutation and policy response shifts the fate of humanity. Design your pathogen, spread across a living world map, and outsmart governments and scientists in a tense race of stealth versus lethality. Evolve transmission routes, symptoms, and resistances, balance visibility to avoid early detection, and exploit climate, travel, and events to gain the upper hand. Multiple scenarios, adaptive AI, and branching mutation trees reward clever planning, while challenge modes and sandbox runs let you test bold strategies.
Screenshots
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How to play:
- Select a pathogen type and difficulty, then pick your Patient Zero starting location on the world map.
- Infect new regions by evolving transmission traits and targeting travel hubs, climates, and population densities.
- Upgrade symptoms and resistances to increase spread and survivability while balancing severity to stay undetected.
- Manage stealth versus lethality by timing dangerous mutations to avoid early shutdowns and border closures.
- Counter global research by disrupting labs, evolving anti-cure traits, and reacting to quarantine, flight bans, and cure progress.
- Complete scenario goals, adapt to dynamic events, and refine your build using genetic modifiers and earned perks.